Review on "High-Density Mapping of Atrial Fibrillation in Humans: Relationship Between High-Frequency Activation and Electrogram Fractionation"

Citation :Yaariv Khaykin.Review on "High-Density Mapping of Atrial Fibrillation in Humans: Relationship Between High-Frequency Activation and Electrogram Fractionation" .JAFIB.2009 Feb;Volume 1 Issue(5): 298-300.

Catheter ablation has rapidly gained acceptance as a mainstay of therapy for many symptomatic patients with atrial fibrillation since the original publication by the Bordeaux group . Early on it became apparent that in most patients with paroxysmal AF, the arrhythmia was initiated by focal firing in the pulmonary veins. Ablation focused on elimination of such triggers and was largely limited to patients who would stay in sinus rhythm long enough to allow successful mapping within the pulmonary veins. As this was time consuming and was associated with high risk of developing pulmonary vein stenosis, ablation lesions were moved further and further away from the sources of focal firing with co-development of Circumferential Pulmonary Vein Ablation (CPVA) aiming to encompass pulmonary vein ostia with circular lesions without verification of conduction block and Segmental Pulmonary Vein Isolation evolving into Pulmonary Vein Antrum Isolation with the targeted area similar to that in CPVA but with requisite documentation of entry and / or exit block of conduction.