Cryoballoon Versus Radiofrequency Ablation For Paroxysmal Atrial Fibrillation: Review Of Current Literature
Syed Rafay Ali Sabzwari, MD; Dhanunjaya Lakkireddy, MD, FACC, FHRS
Atrial fibrillation is the most common arrhythmia affecting an estimated 3 million people in US and 20 million around the world. In the realm of rhythm control antiarrhythmic drugs (AAD) were utilized until transcatheter ablation techniques emerged. Circumferential pulmonary vein isolation (PVI) is the standard and recommended approach for catheter ablation of paroxysmal atrial fibrillation refractory to medical therapy. The first introduced and most commonly used method is radiofrequency (RF) ablation and the second most common and more recent is cryoballoon (CB) ablation. To benefit from their efficacies and optimize their usage, in the past there have been many mostly nonrandamoised single center prospective registries showing equivocal efficacy of the two techniques with slightly lower complications such as cardiac tamponade and perforation with cryoballoon technique. However in addition to the three prior randomized controlled trials, the recently published FIRE and ICE Trial by Kuck et al1 which is a large, multicenter, randomized trial compared radiofrequency and cryoballoon techniques used for ablation of paroxysmal atrial fibrillation.
Syed Rafay Ali Sabzwari, MD; Dhanunjaya Lakkireddy, MD, FACC, FHRS
Atrial fibrillation is the most common arrhythmia affecting an estimated 3 million people in US and 20 million around the world. In the realm of rhythm control antiarrhythmic drugs (AAD) were utilized until transcatheter ablation techniques emerged. Circumferential pulmonary vein isolation (PVI) is the standard and recommended approach for catheter ablation of paroxysmal atrial fibrillation refractory to medical therapy. The first introduced and most commonly used method is radiofrequency (RF) ablation and the second most common and more recent is cryoballoon (CB) ablation. To benefit from their efficacies and optimize their usage, in the past there have been many mostly nonrandamoised single center prospective registries showing equivocal efficacy of the two techniques with slightly lower complications such as cardiac tamponade and perforation with cryoballoon technique. However in addition to the three prior randomized controlled trials, the recently published FIRE and ICE Trial by Kuck et al1 which is a large, multicenter, randomized trial compared radiofrequency and cryoballoon techniques used for ablation of paroxysmal atrial fibrillation.
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